The Weidinger lab at the Institute of Biochemistry and Molecular Biology of Ulm University invites applications for a

PhD student (TV-L 13/65%, f/m/d)
"Does zebrafish heart regeneration depend on anti-aging pathways?"

While heart injury results in permanent damage in adult mammals including humans, zebrafish can efficiently regenerate the heart. Our lab studies the underlying cellular and molecular mechanisms (Bertozzi et al Dev. Biol 2021, Honkoop et al elife 2019, Wu et al Dev. Cell 2016, Zebrowski et al., elife 2015, Schnabel et al., PLOS One 2011). Cardiomyocytes are regenerated from spared differentiated cardiomyocytes, which dedifferentiate and re-enter the cell cycle. Surprisingly, we have found that proliferating cardiomyocytes experience replication stress, which is a major reason for declining regenerative abilities in aged mammals. Zebrafish can overcome the replication stress with the help of BMP signaling. Thus, we speculate that zebrafish heart regeneration depends on an elevated ability to overcome roadblocks that cause declining tissue renewal during aging in mammals, suggesting that zebrafish regeneration can be used to identify anti-aging mechanisms. The successful PhD candidate will use state-of-the art in vivo experiments in zebrafish, including Cre-lox based transgenics, genetic mutants and RNASeq to test this hypothesis and to identify mechanisms by which BMP signaling alleviates replication stress. The project is embedded in a collaborate research initiative (SFB) of Ulm University.

We are looking for an enthusiastic, highly motivated scientist (f/m/d) who is dedicated to performing fundamental research.

We expect:

We offer:



Applications including a CV, a statement of research experience and interests (max. 2 pages), and contact data for 2-3 references should be emailed to Prof. Dr. Gilbert Weidinger, gilbert.weidinger@uni-ulm.de


 

Employment takes place through the administration department of the University Medical Center Ulm, which acts in the name and on behalf of the federal state of Baden-W├╝rttemberg. Handicapped people with equal qualifications will be employed preferentially. Ulm University strives for an increased proportion of women in research and teaching and therefore strongly encourages female qualified scientists to apply for the position. In general, full-time positions are divisible. A subsequent employment is possible.