PhD student (w/m/d) CRC project 1279 The exploration of the human peptidome

The group of Prof. Dr. Barbara Spellerberg at the Institute for Medical Microbiology and Hygiene,  University Hospital Ulm works on antimicrobial peptides within the CRC project 1279 (https://www.uni-ulm.de/med/sfb-1279-home/).  As part of this collaborative project that is conducted together with the group of Prof. Dr. Jan Münch from the Institute of Molecular Virology, we offer a PhD position (starting at the 1st of July 2022) to functionally characterize antimicrobial peptides in regard to their antimicrobial and antibiofilm properties.

Project background
Our project in the CRC 1279 aims at discovering endogenous human peptides displaying antimicrobial functions and at optimizing antimicrobial peptides for potential therapeutic applications. The source for these peptides are peptide libraries generated from body fluids and samples of human organ tissue.  To isolate novel bioactive peptides we are utilizing the comprehensive peptide libraries for the stepwise purification of endogenous compounds detected in specific fractions by repeated rounds of functional assays and separation. This approach allows to isolate antimicrobial peptides from mixtures of up to millions of naturally-occurring compounds. It has proven highly successful and allowed the discovery of novel agents displaying antimicrobial activity. For recent publications generated within the first funding period of the CRC see
https://www.tandfonline.com/doi/full/10.1080/21505594.2020.1831367
https://www.frontiersin.org/articles/10.3389/fmicb.2020.00508/full

Tasks and responsibilities Your profile What we offer





To apply, please send your CV and cover letter till 20.05.2022 to


Prof. Dr. Barbara Spellerberg (barbara.spellerberg@uniklinik-ulm.de) Institut für Medizinische Mikrobiologie und Hygiene, Universitätsklinikum Ulm, Albert Einstein Allee 11 in 89081 Ulm.

Employment takes place through the administration department of the University Medical Center Ulm, which acts in the name and on behalf of the federal state of Baden-Wuerttemberg. Handicapped people with equal qualifications will be employed preferentially. The Ulm University strives for an increased proportion of woman in research and teaching and therefore strongly encourages qualified female scientists to apply for the position.