PhD position open for a 3-4 year period in the project: Mechanistic links between DNA replication dynamics and EMT/stem cell plasticity impacting on therapeutic responsiveness of breast cancer cells
PhD (f/m/d) (65%)

The University Hospital Ulm and its employees stands for a modern and high quality patient care, excellent university research and medical education focused on the future as well as apprenticeships in attractive professional fields. The requirements for this are qualified and committed employees.
We are looking for a PhD student with a pioneer spirit who enjoys to work independently as well as integrated in our interdisciplinary team of scientists. Our research focuses on pathogenic DNA repair and replication mechanisms that drive breast and ovarian tumor formation and represent their Achilles heel to be targeted by therapeutic interventions.
Our recent work on breast and ovarian cancer risk gene products revealed a novel DNA damage tolerance pathway impacting on epithelial-mesenchymal transition (EMT) and stemness. EMT plays important roles during embryogenesis but also tumor progression, release of circulating tumor cells (CTCs) with metastasizing potential and therapeutic responses. The aim of this project will be to elucidate the links between DNA damage tolerance mechanisms at replication forks and EMT/stem cell features in breast cancer cells and their role in metastasis and chemotherapeutic responsiveness (Proc Natl Acad Sci U S A. 2016. 113:E4311; Mol Genet Genomic Med. 2019. 7:e863; Cancers. 2020. 12:930).
Techniques will cover the full range of molecular and cell biological methods from isolation of CTCs, 2D/spheroid/organoid breast cancer cell cultivation, interactome analysis and high content immunofluorescence microscopy to analysis of nascent DNA synthesis.  

We offer
  • access to the International PhD Programme in Molecular Medicine at Ulm University, Germany.  For application requirements visit the website: http://www.uni-ulm.de/mm/
  • funding according to TV-L E13 (65%)
  • a highly interdisciplinary work environment at the University Clinic Ulm and Comprehensive Cancer Center Ulm, with research groups working on basic mechanisms of protein chemistry as well as on patient-derived tumor models
  • access to multiple core facilities including, for example, laser microdissection, proteomics, genomics and multiparametric mass cytometry
  • training in methods and skills as well as qualification and mentoring programs.
Apply if you have
  • Master in Molecular Medicine, Biochemistry, Biology or a related field
  • Previous experience in cell biology and protein biochemistry
  • Strong interest in DNA damage response mechanisms and tumor biology
  • fluent English language skills
To apply, please submit your CV with certificates, prior publications, references and a one-page letter of motivation as single pdf file via email.
 





Contract: limited
Level of employment: part-time
application: 31.10.2020


Applications to:

Lisa Wiesmüller
Division of Gynecological Oncology
Department of Obstetrics and Gynecology at Ulm University
Prittwitzstrasse 43, 89075 Ulm, Germany
Tel.: +49-731-500-58800
E-mail: lisa.wiesmueller@uni-ulm.de
 

The employment occurs by the administration of the hospital in the name and on behalf of the state Baden-Württemberg. Severely handicapped applicants will be given priority in the event of equal suitability. The University Hospital Ulm strives to increase the share of woman in those areas in which they are underrepresented. Appropriately qualified women are asked to apply. A continued employment following the temporary working contract is possible.