The University Hospital Ulm and its employees stands for a modern and high quality patient care, excellent university research and medical education focused on the future as well as apprenticeships in attractive professional fields. The requirements for this are qualified and committed employees.(f/m/d)


PhD student (f/m/d, TV-L 13/65%) - thesis in peripheral nerve trauma research

A position for a PhD thesis (65% / 3 years funding secured) is available in the lab of Prof. Dr. Bernd Knöll under the supervision of Dr. Sofia Meyer zu Reckendorf at the Institute of Physiological Chemistry of Ulm University. The preferred starting time is Jan/Feb 2021.


The project:
Peripheral nerve injuries (PNIs) are diagnosed in 2-3% of patients admitted to trauma centers. Although peripheral nerves have an intrinsic regeneration potential, spontaneous regeneration is limited in humans. Even after surgical intervention, the functional ability is often not restored, which leads to a severe impairment of the patients’ quality of life.
In this project, we want to explore new pharmacological ways to improve nerve regeneration. In our previously published work (Meyer zu Reckendorf et al., Nature Communications, 2020) we identified lipid metabolism as promising candidate for the modulation of nerve regeneration ex vivo. Now, we will employ genetic and pharmacological approaches targeting lipid metabolism in vivo using the sciatic nerve injury model in mice. We will investigate the effects of lipid metabolism modulation on molecular and functional regeneration.
Apart from our mouse model we have the unique opportunity to investigate human nerve samples ex vivo after injury. In this case, we are interested to analyze how human nerves react to drugs modulating the lipid metabolism. Since the initial nerve injury can lay several months back until it is recognized and treated, we want to know if this latency in treatment alters the responsiveness of nerves to drug Treatment.


We expect:

We offer:

Further information about our lab can be found at:
https://www.uni-ulm.de/med/med-physchem/ag-knoell/
 

Applications including a CV, a short statement of your research interests and experience (max. 2 pages) and contact data for 2 references should be emailed to Dr. Sofia Meyer zu Reckendorf, sofia.meyer-zu-reckendorf@uni-ulm.de.
 

The employment occurs by the administration of the hospital in the name and on behalf of the state Baden-Württemberg. Severely handicapped applicants will be given priority in the event of equal suitability. The University Hospital Ulm strives to increase the share of woman in those areas in which they are underrepresented. Appropriately qualified women are asked to apply. A continued employment following the temporary working contract is possible.